The CleanX SAX SPE Cartridges are designed with high-purity spherical silica functionalized with quaternary amine groups, providing a strong anion exchange mechanism ideal for the extraction and cleanup of weak anionic compounds, such as carboxylic acids.The strong, permanent positive charge of the SAX sorbent ensures efficient retention and selective elution of weak acids, anions, and ionic contaminants from complex matrices.CleanX SAX is also frequently used for desalting biological macromolecules and removing strong anions including nucleic acids, nucleotides, sulfates, and inorganic ions, making it an indispensable choice for bioanalytical, environmental, and clinical applicationsThe CleanX SAX sorbent utilizes quaternary ammonium functional groups to maintain a permanent positive charge, ensuring strong and selective binding of negatively charged analytes across a wide pH range.This robust chemistry provides high recovery for weak acids and allows for controlled elution through pH or ionic strength adjustments.Its spherical silica base guarantees smooth flow dynamics, reproducible extractions, and superior cleanup of complex biological and environmental matrices.