The NovaSil® C18 column represents one of the most advanced and versatile C18 phases available, engineered to deliver exceptional stability and performance across a wide pH range. With superior resistance to both highly acidic and alkaline conditions (pH 1–12), NovaSil® C18 ensures reliable operation even in the most demanding chromatographic applications. Its high surface area design provides strong retention for both hydrophobic and polar compounds, enabling outstanding separation efficiency and peak resolution.As the most hydrophobic phase among C18 columns, NovaSil® C18 is perfectly suited for the separation of acidic, neutral, and basic organic compounds, as well as pharmaceutical raw materials, intermediates, finished formulations, and peptides. The column’s excellent column-to-column reproducibility guarantees consistent results across analyses, while its compatibility with both pure organic and mixed aqueous/organic mobile phases makes it ideal for a broad range of analytical and preparative HPLC methods. Designed for durability, selectivity, and versatility, NovaSil® C18 is the ultimate solution for precise, high-performance chromatographic separations.