ChromX® C18-AQ by CHROMOSEP is a specialized dual-mode reverse phase (RP) HPLC column designed to deliver superior performance in aqueous environments. The C18 stationary phase, embedded with polar end-capping molecules, ensures complete compatibility with 100% aqueous mobile phases, preventing phase collapse and maintaining consistent retention. This innovative design allows ChromX® C18-AQ to provide enhanced interaction with hydrophilic and polar analytes, making it ideal for the separation of water-soluble compounds, metabolites, and polar pharmaceuticals. With improved retention for hydrophilic molecules and excellent peak shape stability, this column offers high reproducibility, durability, and selectivity across a broad range of applications. ChromX® C18-AQ is the preferred choice for laboratories requiring precise, reliable separations in fully aqueous or mixed-mode chromatographic conditions.