The CleanX SCX SPE Cartridges are made from high-purity spherical silica gel functionalized with benzene sulfonic acid groups, providing powerful strong cation exchange capabilities. This sorbent is specifically engineered for the extraction of organic base compounds and the desalting of biological macromolecules, ensuring superior reproducibility and analytical performance.When combined with C18 reversed-phase sorbents, CleanX SCX enables selective cleanup of complex biological samples containing antibiotics, amphoteric acids, carbohydrates, nucleotides, surfactants, and nucleic acid bases, making it ideal for both research and routine testing laboratories.The CleanX SCX sorbent utilizes benzene sulfonic acid functionalization to create a permanent negative charge on the silica surface, enabling strong ionic attraction with positively charged (basic) analytes.This chemistry ensures excellent binding capacity and selectivity for organic bases, even in high-salt or complex matrices.When used in tandem with C18 reversed-phase sorbents, SCX provides a comprehensive cleanup system capable of handling a wide polarity range of compounds in one workflow.